DIFFERENTIATED MECHANISM FOR TREATMENT OF INFLAMMATION
IW-601 is a monoclonal antibody that prevents monocytes & neutrophils from entering inflamed tissues
- IW-601 is an antibody that specifically targets MOSPD2, a newly discovered adhesion checkpoint on the surface of myeloid cells (more specifically on monocytes and neutrophils).
- Inhibition of MOSPD2 locks these immune cells in a sticky state by activating β2-integrin (an adhesion protein) thereby preventing their entrance into inflammatory tissues and reducing the propagation of immune responses.
- IW-601’s novel mechanism offers potential advantages over traditional approaches by overcoming the redundancy of chemotaxis pathways and directly modulating tissue inflammation without depleting immune cells.